Refine your search
Collections
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Prasad, Pushpa
- Chemopreventive Potential of Aegle marmelos Fruit Extract against 7,12-dimethylbenz(a)Anthracene-Induced Skin Papillomagenesis in Mice
Abstract Views :249 |
PDF Views:0
Authors
Affiliations
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), IN
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), IN
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 2 (2012), Pagination: 87-90Abstract
The present investigation was undertaken to explore the chemopreventive action of Aegle marmelos fruit extract on 2-stage carcinogenesis, induced by a single topical application of 7, 12-Dimethylbenz(a)anthracene (DMBA) (104μg/100μl acetone), and one week later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks) in Swiss albino mice. Single topical application of Aegle marmelos fruit extract at a dose of 900 mg/kg b.w. along with DMBA+Croton oil was found to be effective in decreasing the cumulative number of papillomas, tumor incidence, tumor yield and tumor burden as compared to control group (p<0.05). The depleted levels of glutathione were also restored in Aegle marmelos fruit extract treated group. Thus, the present study revealed the chemopreventive role of Aegle marmelos fruit extracts against DMBA-induced skin carcinogenesis in mice.Keywords
Chemopreventive, Aegle marmelos, DMBA, Papilloma, Skin Carcinogenesis, Glutathione.
References
- Arul V, Miyazaki S and Dhananjayan R (2005): Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Correa. Journal of Ethnopharmacology, 96(1), 159- 163.
- Arumugam S, Kavimani S, Kadalmani B, Ahmed ABA, Akbarsha MA, Rao MV (2008): Antidiabetic activity of leaf and callus extracts of Aegle marmelos in rabbit. Science Asia, 34, 317-321.
- Ather M (2002): Oxidative stress and experimental carcinogenesis. Indian J Exp Biol, 40, 656-667.
- Agrawal RC, Jain R, Raja W and Ovais M (2009): Anticarcinogenic effects of Solanum lycopersicum fruit extract on Swiss albino and C57BL mice. Asian Pacific Journal of Cancer prevention, 10(1-4), 379-382.
- Berenblum I and Shubik P (1947): A new quantitative approach to the study of stages of Chemical carcinogenesis in the mouse skin. Brit J Cancer, 1, 383-387.
- Berenblum I (1975): Sequqntial aspects of chemical carcinogenesis: skin in cancer “A comprehensive treatise”. Plenum Press, New York, 1, 323-344.
- Beutler E, Duron O, Kellin BM (1963): Improved method for the determination of blood glutathione. Journal of Laboratory and Clinical Medicine, 61, 882-888.
- Brijesh S, Daswani P, Tetali P, Anita N, Birdi T (2009): Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruits: Validating its traditional usage. BMC complementary and Alternative medicine, 9(47), 1-12.
- Bystrianyk R (2005): Aloe helps block cancer. J Toxicol Environ health, 17, 45-49.
- Chaudhary G, Saini MR, Goyal PK (2007): Chemopreventive potential of Aloe vera against 7, 12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice. Integrative cancer Therapies, 6(4), 405-412.
- Copeland ES (1983): A national institute of health workshop report. Free radical in promotion. A chemical pathology study section workshop. Cancer Research, 43, 5631-5637.
- Jagetia GC, Venkatesh P, Baliga MS (2005): Aegle marmelos (L.) Correa Inhibits the proliferation of Transplanted Ehrlich Ascites Carcinoma in mice. Biol. Pharm. Bulletin, 28(1), 58-64.
- Lampronti I, Martello D, Bianchi N, Borgatti M, Lambertini E, Piva R, Jabbar S, Choudhari MS, Khan MT, Gambari R (2003): Antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Correa. Phytomedicine, 10(4), 300-308.
- Moron MS, Depierre JW and Mannervik B (1979): Levels of Glutathione, Glutathione Reductase and Glutathione-s-transferase activities in rat lung and liver. Biochimica et Biophysica Acta, 582, 67-78.
- Morse EC, Stoner G (1996): Cancer chemoprevention: principles and prospects. Carcinogenesis, 14, 1737-1746.
- Lewis JG and Adams DO (1987): Early inflammatory changes in the skin of Sencer and C57B2/6 mice following exposure to 12-Otetradecanoyl phorbol-13-acetate. Carcinogenesis, 8, 889-898.
- Nugroho AE, Riyanto S, Sukari MA, Maeyama K (2010): Effects of Skimmianine, a quinoline alkaloid of Aegle marmelos Correa ischolar_mains, on the Histamine release from rat mast cells. Journal of Basic and applied Sciences, 6(2), 141-148.
- Oberley TD and Oberley LW (1993): Oxygen radicals and cancer. In free radicals in Ageing' EdYuBP, CRC Press, Boca Raton, FL, pg-247-267.
- Narendra T, Shweta S, Tiwari P, Reddy KP, Khaliq T, Prathipati P, Puri A, Srivastava AK, Chander R, Agarwal SC, Raj K (2007): Antihyperglycemic and antidyslipidemic agent from Aegle marmelos. Bioorg Med Chem Letters, 17(6), 1808-1811.
- Meena PD, Kaushik P, Shukla S, Soni AK, Kumar M, Kumar A (2006): Anticancer and antimutagenic properties of Acacia nilotica (Linn) on 7, 12-dimethylbenz(a)anthracene induced skin papillomagenesis in Swiss Albino mice. Asian pacific Journal of cancer prevention, 7, 627-632.
- Sabu MC and Kuttan R (2004): Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties. Indian J. Physiol Pharmacology, 48(1), 81-88.
- Samarasekera I and Krishnamurti JK (2004): Isolation of various coumarin present in the various parts of the Aegle marmelos. Nat. Prod. Res., 18(2), 117-132.
- Singanan V, Singanan M and Begum H (2007): The hepatoprotective effect of Bael leaves (Aegle marmelos) in alcohol induced liver injury in Albino rats. International Journal of Science and Technology, 2(2), 83-92.
- Upadhya S, Shanbhag KK, G Suneetha, Naidu, Upadhya S (2004): A study of Hypoglycemic and antioxidant activity of Aegle marmelos in Alloxan induced diabetic rats. Indian Journal of Physiol Pharmacology, 48(4), 476-480.
- Preliminary Phytochemical Screening and In Vitro Antioxidant Properties of the Pleurotus ostreatus extract
Abstract Views :281 |
PDF Views:2
Authors
Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur-493111 (C.G.), IN
1 Columbia Institute of Pharmacy, Tekari, Raipur-493111 (C.G.), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 3 (2014), Pagination: 135-138Abstract
The free radical amassed in the body due to oxidative stress, and plays the leading part in the inception of disease. Presently researchers are working on natural antioxidant, because it has minimum toxic effect compared to chemical substances. Pleurotus ostreatus extract were evaluated for phytochemical composition and to assess in vitro antioxidant activities. In the course of preliminary phytochemical analysis, the petroleum ether extract, ethyl acetate extracts and ethanol extracts of P. ostreatus was evaluated to determine the presence of secondary metabolites. Antioxidant activity of the ethanol extract of P. ostreatus was assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH), Super oxide free radical scavenging assay (SOD) and total polyphenol content. Preliminary phytochemical screening of ethanol extract revealed the presence of phenolic compounds, flavonoids, alkaloids and glycoside, while petroleum ether and ethyl acetate extracts were devoid from these phytoconstituent. The ethanol extract scavenged DPPH radical and superoxide radical with the IC50 being 69.30 μg/ml and 107.05 μg/ml respectively. The ethanol extract of P. ostreatus revealed 83.47 ± 1.53 mg/100 gm of total polyphenol content. The finding endorses that P. ostreatus acquire high antioxidant activities, and it may uses as natural antioxidant for the healing of various diseases.Keywords
Pleurotus ostreatus, DPPH, Antioxidant, Phytochemical.References
- Sharma S, Pal A. Preliminary Phytochemical Screening and In Vitro Antioxidant Activities of Parkinsonia aculeata Linn. BioMed Research International. 2014; 2014: 1-8.
- Aiyegoro OA, Okoh AI. Preliminary phytochemical screening and In vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC. BMC Complementary and Alternative Medicine. 2010, 10(21): 1-8.
- Kenwat R, Prasad P, Sahu RK, Roy A, Saraf S. Preliminary Phytochemical Screening and In Vitro Antioxidant Efficacy of Fruit Oil of Martynia annua. UK Journal of Pharmaceutical and Biosciences. 2014; 2(1), 16-22.
- Kumar G, Karthik L, Rao KVB. Phytochemical composition and in vitro antioxidant activity of aqueous extract of Aerva lanata (L.) Juss. ex Schult. Stem (Amaranthaceae). Asian Pacific Journal of Tropical Medicine. 2013; 180-187.
- Arvind K, Singh S, Mahour K, Vihan VS, Gururaj K. Phytochemical Analysis of Some Indigenous Plants Potent Against Ectoparasite. Asian J of Exp Biol Sci. 2011; 2: 506-509.A
- Sahu RK, Singh H, Roy A. Antioxidative characteristics of ethanol and aqueous extracts of Curcuma amada rhizomes. Research J. Pharmacognosy and Phytochemistry. 2009: 1(01): 41-43.
- Sharma U, Sahu RK, Roy A, Golwala DK. In vivo antidiabetic and antioxidant potential of Stephania hernandifolia in streptozotocin-induced-diabetic rats. Journal of Young Pharmacists. 2010: 2(3): 255-260.
- Pasko P, Barton H, Zagrodzki P, Gorinstein S, Fo1ta M, Zachwieja Z. Anthocyanins, total polyphenols and antioxidant activity in amaranth and quinoa seeds and sprouts during their growth. Food Chemistry. 2009; 115: 994-998.
- Chlopicka J, Pasko P, Gorinstein S, Jedryas A, Zagrodzki P. Total phenolic and total flavonoid content, antioxidant activity and sensory evaluation of pseudo cereal breads. LWT - Food Science and Technology. 2012; 46: 548-555.
- Gupta AK, Ahirwar NK, Shinde N, Choudhary M, Rajput YS, Singh A. Phytochemical Screening and Antimicrobial Assessment of Leaves of Adhatoda vasica, Azadirachta indica and Datura stramonium. UK Journal of Pharmaceutical and Biosciences. 2013; 1(1): 42-47.